Tulley, a once-promising literary star now biding his time as an advertising copy editor, moves from cynicism to acceptance as he secretly hopes to write a great novel only to learn that his life of booze will end all too soon. Levine, his best friend and Natalie, the woman who might have saved him, suffer the pain of Tulley's anger and rejection.
When a new dad (Justin Bartha) has to return home to bury his estranged father, things take a turn for the complicated when the dead man's final wish is to have his ashes scattered on the field of his favorite professional sports team.
In the near future, breathable air is nonexistent. Virtually all of humanity has disappeared, and those chosen to reestablish society reside in a controlled state of suspended animation. Two engineers tasked with guarding the last hope for mankind struggle to preserve their own sanity and lives while administering to the vital task at hand.